Enhanced susceptibility of cis‐diamminedichloroplatinum‐treated K562 cells to lysis by peripheral blood lymphocytes and lymphokine activated killer cells

Abstract

These results demonstrate that CDDP has a direct effect on the K562 target cells, rendering them more susceptible to lysis by PBL, NK cells, and LAK cells. In addition, the result suggest that CDDP-mediated enhancement of target cell lysis is not attributable to changes of surface membrane antigen expression or recruitment of precursor cells but to processing of CDDP by the cells. The possible mechanisms of the effect of CDDP on K562 cells and clinical implications are discussed.