Sympathetic ophthalmitis treated with azathioprine.

Abstract

THIS drug with the chemical name 6-(1-methyl-4-nitro-5-imidazolyl) thiopurinet (Figure) was developed as part of a programme designed to present the thiopurines in a masked, but metabolically active form, in order to treat adenocarcinoma in rodents (Elion, Callahan, Bieber, Hitchings, and Rundles, 1961; Elion, Bieber and Hitchings, 1960; Hitchings and Elion, 1959) and chronic granulocyctic and acute leukaemia in man (Rundles, Laszlo, Itoga, Hobson, and Garrison, 1961).