Native and oxidized low density lipoproteins oppositely modulate the effects of insulin-like growth factor I on VSMC

Abstract

Our study demonstrates a previously unidentified modulation of the actions of IGF-I on A10 VSMC by LDL, dependent on their extent of oxidative modification. Our findings suggest that the differential modulation of the PI3 kinase/Akt response to IGF-I play a pivotal role.