C4d-Fixing Capability of Low-Level Donor-Specific HLA Antibodies Is Not Predictive for Early Antibody-Mediated Rejection

Abstract

The pretransplant capability of low-level HLA-DSA to trigger C4d fixation in vitro is not predictive for early AMR or C4d deposition in peritubular capillaries in vivo. This argues against pretransplant C4d SAFB testing to define the clinical relevance of low-level HLA-DSA.