Antioxidants Inhibit Ethanol-Induced Gastric Injury in the Rat: Role of Manganese, Glycine, and Carotene

Abstract

Ethanol-induced gastric mucosal damage may involve generation of oxygen-derived radicals, independent of the xanthine oxidase system. By acting as oxygen radical scavengers, Mn2+, glycine, and carotenes, like catalase and DMTU, provide significant gastroprotection.