A Mild Method for the Esterification of Fatty Acids

Abstract

Abstract In conjunction with a synthetic problem, we were in need of a method for the stoichiometric esterification of fatty acids, containing the aqueous acid labile tert-butyl dimethylsilyloxy group (OTBS), with a variety of alcohols. It has been reported2 that fatty acids form acylureas in the presence of dicyclo-hexylcarbodiimide (DCC) and methanol3 without esterification.