VEGF Can Act as Vascular Permeability Factor in the Hepatic Sinusoids through Upregulation of Porosity of Endothelial Cells

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

Donald R. Senger, Stephen J. Galli, Ann M. Dvořàk et al. · Science · 1983 · 4K citations

Medicine, Biochemistry, Oncology +13

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

Guo‐Hua Fong, Janet Rossant, Marina Gertsenstein et al. · Nature · 1995 · 2.6K citations

Life Sciences, Cell Biology, Molecular Biology +13

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

Sachie Hiratsuka, Osamu Minowa, Junko Kuno et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations

Life Sciences, Developmental Biology, Genetics +15

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

Tomoko Takahashi, Hikaru Ueno, Masabumi Shibuya · Oncogene · 1999 · 574 citations

Life Sciences, Genetics, Molecular Biology +14

Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.

David A. Antonetti, Alistair J. Barber, S Khin et al. · Diabetes · 1998 · 572 citations

Medicine, Cell Biology, Ophthalmology +16