Concepedia

Publication | Open Access

Berberine Induces hERG Channel Deficiency through Trafficking Inhibition

DOIFull Paper Access

22

Citations

18

References

2014

Year

Kaiping Zhang, Duo Zhi, Ting Huang, Yan Gong, Meng Yan, Chen Liu, Ting Wei, Zengxiang Dong, Baoxin Li, Baofeng Yang
Cellular Physiology and Biochemistry

Abstract

Our study demonstrates that BBR induces hERG channel deficiency by inhibiting channel trafficking after incubation for 24h. Trafficking inhibition activated the UPR, and the ER-restricted hERG was ubiquitinized and degraded in lysosomes and proteasomes.

References

YearCitations

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