Dose-dependent effects of capsaicin nasal challenge: In vivo evidence of human airway neurogenic inflammation

Abstract

Capsaicin-sensitive nerve stimulation in subjects with active allergic rhinitis produces reproducible and dose-dependent leukocyte influx, albumin leakage, and glandular secretion. These results provide in vivo evidence for the occurrence of neurogenic inflammation in the human upper airway with active allergic disease.