Nucleic Acids Research · 1984 · 605 citations · 39 references
Life SciencesBioinformaticsMolecular BiologyComputational BiologyGenomicsSequence AnalysisDna SequencingProtein Sequence AnalysisRestriction Enzyme TechnologySequence AlignmentSequence Similarity SearchDna Sequence Data AnalysisEnzymesHomologyRestriction Enzyme DigestionSequence Homology Detection
We have developed a versatile program for the analysis of nucleic acid and protein sequences on the IBM Personal Computer. The program is interactive and self-instructing. It contains all the features generally found in sequence analysis programs on large computers, including extensive homology routines, as well as new procedures for the entry of sequence data. The program contains facilities to store and utilize the entire Nucleic Acid Sequence Data Bank. We have devised a new algorithm to find restriction enzyme sites, which allows our microcomputer program to find all sites on a small plasmid for 100 different enzymes in 1 to 2 minutes.
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Prediction of protein conformation
Peter Y. Chou, Gerald D. Fasman · Biochemistry · 1974 · 3.3K citations
Improved Estimation of Secondary Structure in Ribonucleic Acids
Ignacio Tinoco, Philip N. Borer, Barbara Dengler et al. · Nature New Biology · 1973 · 2.3K citations
Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor
Shigetada Nakanishi, Akira Inoue, Toru Kita et al. · Nature · 1979 · 1.8K citations