Concepedia

IBX‐Mediated Oxidative Ugi‐Type Multicomponent Reactions: Application to the N and C1 Functionalization of Tetrahydroisoquinoline

Tifelle Ngouansavanh, Jieping Zhu

Angewandte Chemie International Edition · 2007 · 173 citations · 51 references

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Concepts

Abstract

Ugi wonderland: An Ugi-type reaction of tetrahydroisoquinoline with an isocyanide and a carboxylic acid in the presence of iodoxybenzoic acid (IBX) afforded the 1,2-diacylated adduct in good to excellent yields (see scheme).

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C-H Bond Functionalization in Complex Organic Synthesis

Kamil Godula, Dalibor Sameš · Science · 2006 · 2.1K citations

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Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of Heterocycles

Jieping Zhu · European Journal of Organic Chemistry · 2003 · 943 citations · Full text

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Recent Advances in Solution-PhaseMulticomponent Methodology for the Synthesis of HeterocyclicCompounds

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Cu-catalyzed cross-dehydrogenative coupling: A versatile strategy for C–C bond formations via the oxidative activation of sp <sup>3</sup> C–H bonds

Zhiping Li, D. Scott Bohle, Chao‐Jun Li · Proceedings of the National Academy of Sciences · 2006 · 592 citations · Full text

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Highly Efficient Copper-Catalyzed Nitro-Mannich Type Reaction:  Cross-Dehydrogenative-Coupling between sp<sup>3</sup> C−H Bond and sp<sup>3</sup> C−H Bond

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2005 · 538 citations

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