3,5-Dichloro-4-pyridinecarbonitrile as a Key Reagent in a Synthesis of Copper Containing Amine Oxidase Inhibitors

Abstract

&&tact -Various synthetic approaches to 3,4,5-trifunctionalized pyridine derivatives useful as benzylamine oxidase inhibitors are extensively explored.FuIly satisfactory preparations of the inhibitors 3.5-diethoxy-4-aminomethylpyridine (4).3,5-bis(3-hydroxypropoxy)-4-aminomethylpy~idine (11)..3,5-bis(4-hydroxybutoxy)-4-aminomethylpyridine(12) and 3-ethoxy-5-phenylmethoxy-4-aminomethylpyridine (16), all in the form of dihydrochloride salt, using 3.5-dichloro-4pyridinecarbonitrile as key precursor, are reported.