Direct Method for Carbon–Carbon Bond Formation: The Functional Group Tolerant Cobalt‐Catalyzed Alkylation of Aryl Halides

Abstract

A new protocol for the direct cobalt-catalyzed alkylation of aryl halides has been developed that proceeds smoothly in the presence of phosphanes or bipyridines as ligands with a variety of alkyl halides, including challenging alkyl electrophiles bearing β-hydrogen atoms (see scheme). Sensitive functional groups are tolerated on both coupling partners, thus, significantly extending the general scope of transition-metal-catalyzed alkylation of aryl halides.