Procarbazine (Natulan) in the Treatment of Peyronie's Disease

Abstract

Summary— Thirty‐four men with Peyronie's diseases were treated with a 12‐week course of the drug procabazine (Natulan), preceded or followed by a 12‐week course of vitamin E. Ninety‐one per cent of the men failed to improve or became worse whilst receiving Natulan and toxic side‐effects were common. In comparision 39% improved whilst taking vitamin E. We conclude that Natulan is of little benefit in the treatment of this condition and may indeed be harmful.