Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives

Three-Dimensional Models of Wild-Type and Mutated Forms of Cytochrome P450 14α-Sterol Demethylases from <i>Aspergillus fumigatus</i> and <i>Candida albicans</i> Provide Insights into Posaconazole Binding

Xiao Li, Vincent Madison, Andrew S. Chau et al. · Antimicrobial Agents and Chemotherapy · 2004 · 268 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

A Three-Dimensional Model of Lanosterol 14α-Demethylase of <i>Candida albicans</i> and Its Interaction with Azole Antifungals

Haitao Ji, Wannian Zhang, Youjun Zhou et al. · Journal of Medicinal Chemistry · 2000 · 210 citations

Life Sciences, Biochemistry, Microbiology +17

Structure-Based Optimization of Azole Antifungal Agents by CoMFA, CoMSIA, and Molecular Docking

Chunquan Sheng, Wannian Zhang, Haitao Ji et al. · Journal of Medicinal Chemistry · 2006 · 182 citations

Pharmacy, Medicinal Chemistry, Drug Design +16

Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase (CYP51)

Qingyan Sun, Jianming Xu, Yongbing Cao et al. · European Journal of Medicinal Chemistry · 2007 · 47 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Identification of Y118 Amino Acid Residue in Candida albicans Sterol 14.ALPHA.-Demethylase Associated with the Enzyme Activity and Selective Antifungal Activity of Azole Analogues

Shuanghong Chen, Chunquan Sheng, Xiaohui Xu et al. · Biological and Pharmaceutical Bulletin · 2007 · 44 citations · Full text

Life Sciences, Biochemistry, Microbiology +17