Diastereoselective Addition of Prochiral Metallo Enolates to Chiral 1-Acylpyridinium Salts

N-methoxy-n-methylamides as effective acylating agents

Steven Nahm, Steven M. Weinreb · Tetrahedron Letters · 1981 · 1.8K citations

Pharmacy, Medicinal Chemistry, Pharmacology +5

Acyclic stereoselection. 7. Stereoselective synthesis of 2-alkyl-3-hydroxy carbonyl compounds by aldol condensation

Clayton H. Heathcock, Charles T. Buse, William A. Kleschick et al. · The Journal of Organic Chemistry · 1980 · 443 citations

Natural Sciences, Chemistry, Mass Spectrometric Analysis +9

Asymmetric Synthesis of 2-Alkyl(Aryl)-2,3-dihydro-4-pyridones by Addition of Grignard Reagents to Chiral 1-Acyl-4-methoxypyridinium Salts

Daniel L. Comins, Sajan P. Joseph, R. Richard Goehring · Journal of the American Chemical Society · 1994 · 215 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Trimethylsilyl trifltate catalyzed aldol-type reaction of enol silyl ethers and acetals or related compounds

Shizuaki Murata, Masaaki Suzuki, Ryōji Noyori · Tetrahedron · 1988 · 150 citations

Natural Sciences, Chemistry, Catalysis +10

Efficient method for preparation of N-methoxy-N-methyl amides by reaction of lactones or esters with Me2AlClMeONHMe·HCl

Takeshi Shimizu, Katsuhisa Osako, T. Nakata · Tetrahedron Letters · 1997 · 96 citations

Natural Sciences, Chemistry, Medicinal Chemistry +3