Progressive Multifocal Leukoencephalopathy in a Male Homosexual with T-Cell Immune Deficiency

Abstract

AN acquired immune deficiency in male homosexuals that is manifested by infection with one or more opportunistic microorganisms has recently been recognized. These agents have included cytomegalovirus, Toxoplasma gondii, Pneumocystis carinii, Candida albicans, Mycobacterium avium–intracellulare, and Cryptococcus neoformans.1 2 3 4 A prolonged clinical course with an otherwise self-limited infection, such as herpes simplex infection, has also been described,3 and a remarkable incidence of Kaposi's sarcoma has been reported.1 2 3 4 5 In this milieu, the occurrence of progressive multifocal leukoencephalopathy (PML) might be expected. We present the case of a male homosexual with a T-cell immune deficiency, in whom PML . . .