The Breast Cancer Susceptibility Mutation <i>PALB2 1592delT</i> Is Associated with an Aggressive Tumor Phenotype

Abstract

The PALB2 1592delT mutation has a strong effect on familial breast cancer risk. The tumors rising in patients carrying this mutation manifest a phenotype associated with aggressive disease. Our results also suggest a significant impact of carrying a BRCA2 mutation on long-term breast cancer survival.