Proceedings of the National Academy of Sciences · 1970 · 207 citations · 10 references
Life SciencesCell BiologyDevelopmental BiologyCell DifferentiationMorphogenesisPlant BiochemistryCell Wall BiochemistryCell Wall BiosynthesisCell Wall PhysiologyCell Wall StructureFungal DevelopmentVacuole BiologyCatabolic SignalingFruiting Body InductionVacuole Morphology
Cyclic AMP, which is a cell attractant (acrasin) for Dictyostelium discoideum, will cause isolated, unaggregated cells to turn directly into stalk cells containing thick celluloselike walls and large vacuoles. From previous work we know that in the cell mass, acrasin is produced solely in the region of stalk formation during fruiting, that stalk formation involves a high level of catabolism, and that cyclic AMP stimulates catabolic enzymes in other systems. These facts obviously suggest that in the development of D. discoideum, cyclic AMP might be a key factor in stalk cell differentiation.
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The acrasin activity of adenosine-3',5'-cyclic phosphate.
Théo M. Konijn, J G Van De Meene, John Tyler Bonner et al. · Proceedings of the National Academy of Sciences · 1967 · 503 citations · Full text
Life Sciences, Ecology, Microbiology +15