Ultrastructural Properties in Cortical Bone Vary Greatly in Two Inbred Strains of Mice as Assessed by Synchrotron Light Based Micro- and Nano-CT

Abstract

We established a strategy to subdivide murine intracortical porosity into ultrastructural phenotypes, namely the canal network and the osteocyte lacunar system. Nondestructive global and local SR-based CT methods have been designed for 3D quantification and subsequent morphometric analysis of these phenotypes. Results in the two different mouse strains C57BL/6J-Ghrhr(lit)/J and C3.B6-Ghrhr(lit)/J showed that the cannular and lacunar morphometry and the biomechanical properties were fundamentally different.