Wake-promoting agent modafinil worsened attentional performance following REM sleep deprivation in a young-adult rat model of 5-choice serial reaction time task

Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker

Charles A. Czeisler, Jeanne F. Duffy, Theresa L. Shanahan et al. · Science · 1999 · 1.7K citations

Nursing, Endocrinology, Physiology +17

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

Jim J. Hagan, Ron A. Leslie, Sara Patel et al. · Proceedings of the National Academy of Sciences · 1999 · 1.2K citations

Life Sciences, Neurobiology, Neuroscience +17

Reconciling the role of central serotonin neurons in human and animal behavior

Philippe Soubrié · Behavioral and Brain Sciences · 1986 · 1K citations

Medicine, Neuroscience, Pharmacology +17

Cognitive enhancing effects of modafinil in healthy volunteers

Danielle C. Turner, Trevor W. Robbins, Luke Clark et al. · Psychopharmacology · 2003 · 519 citations

Medicine, Neuroscience, Pharmacology +7

Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons

Patrice Bourgin, Salvador Huitrón‐Reséndiz, Avron D. Spier et al. · Journal of Neuroscience · 2000 · 505 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16