Publication | Closed Access
Activation of human platelet protein kinase C-ß<sub>2</sub> in vivo in response to acute hyperglycemia
15
Citations
0
References
2009
Year
Normal ControlsImmunologyBlood CellPathologyInsulin SignalingInflammationThrombosisMetabolic SyndromeElevated GlucoseReceptor Tyrosine KinaseHematologyHuman Platelet ProteinImmune BlotsCell SignalingHealth SciencesMolecular PhysiologyInsulin ManagementVascular BiologyDiabetes ComplicationsCell BiologyThrombopoiesisSignal TransductionBlood PlateletPhysiologyDiabetesDiabetes MellitusHyperglycemiaMedicine
Protein kinase C (PKC) is known to be activated in experimental model systems by elevated glucose and may play an important role in the pathogenesis of diabetic complications. Since there is no information about its role in humans in vivo we investigated the activation of PKC in human thrombocytes during infusion of glucose and insulin in normal controls and in 19 NIDDM patients by determining membrane and cytosol levels of PKCß2 using immune blots.