Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation

Abstract

Periostin is a fibrogenic protein that mediates fibroblast differentiation and extracellular matrix synthesis. Here, we show that periostin is dynamically and temporally expressed during skin development, is induced by TGF-beta1 in vitro and is significantly upregulated during wound repair as well as cutaneous pathologies.