Differential Binding of the Transcription Factors Sp1, AP-1, and NFI to the Promoter of the Human α5 Integrin Gene Dictates Its Transcriptional Activity

Abstract

These results suggest that alpha5 gene expression is likely dictated by subtle alterations in the nuclear ratio of TFs that either repress (NFI) or activate (Sp1 and AP-1) alpha5 transcription in corneal epithelial cells.