Tissue Antigens · 1976 · 27 citations · 12 references
MedicineGeneticsImmunologyDiabetologyImmunogeneticsKidney TransplantationDiabetes MellitusDiabetic RetinopathyGlomerular DiseasesHistocompatibilityHla MatchingHla TypingDiabetes-related ComplicationsDiabetic GlomerulosclerosisDiabetic Renal MicroangiopathyDiabetic VasculopathyKidney Transplant CareKidney Transplant PreparationOcular Manifestations Of DiabetesSmall Vessel Nephropathy
To gain further insight into the genetic determinants of diabetic small vessel disease, we studied 22 HLA antigens in 110 juvenile-onset, insulin-dependent diabetics with terminal glomerulosclerosis and retinopathy, who were being prepared for kidney transplant. HLA antigens were comtemporarily determined in non-diabetic kidney transplant recipients and healthy controls. The frequency of antigens A1 and B8 were significantly higher in diabetics than in controls (P less than .02 and .011), but the frequency of BW15 was normal. The data are compatible with the concept that juvenile diabetes with microangiopathy is one of the HLA-B8 associated disorders.
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HL-A ANTIGENS AND DIABETES MELLITUS
Jørn Nerup, P. Platz, Ole Andersen et al. · The Lancet · 1974 · 814 citations
A SIMPLE MICRO CYTOTOXICITY TEST
D. Bernard Amos, H. Bashir, W Boyle et al. · Transplantation · 1969 · 443 citations