Science · 1982 · 273 citations · 13 references
Life SciencesEndocrinologyPhysiologyNeuroendocrinologySteroid BiochemistryStress PhysiologyAdrenal EndocrinologyAdrenal HormonesAdrenal Steroid HormonesHormone ReleaseHormone SecretionNeuroendocrine PhysiologyAdrenal Cortex FunctionAdrenal Cortex PhysiologyAdrenocortical SecretionAdrenocorticotropic Hormone RegulationAdrenocorticotropic Hormone SecretionAntiserum PreparationHypothalamic-pituitary-adrenal FeedbackPituitary-adrenal Interaction
Intravenous administration of rabbit antiserum to ovine corticotropin-releasing factor (CRF) markedly reduced the CRF-induced rise of plasma adrenocorticotropic hormone (ACTH) in intact nonstressed adult male rats while blocking more than 75 percent of the ACTH release observed in rats exposed to ether stress. Furthermore, antiserum to CRF significantly lowered ACTH levels in adrenalectomized animals. These results suggest that endogenous CRF plays a physiological role in regulating ACTH secretion.
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