Structure elucidation of the macrocyclic antibiotic lipiarmycin

Abstract

By a combination of chemical degradations and 1H and 13C n.m.r. studies, the structure of the antibiotic lipiarmycin, produced by Actinoplanes deccanensis, has been elucidated. The molecule contains two glycosyl moieties, namely 2-O-methyl-4-O-homodichloro-orsellinate-β-D-rhamnose and 4-O-isobutyrate-5-methyl-β-rhamnose, attached to a 18-membered unsaturated lactone ring.