μ, but not κ, opioid agonists induce contractions of the canine small intestine ex vivo

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

Opiate Receptor: Demonstration in Nervous Tissue

Candace B. Pert, Solomon H. Snyder · Science · 1973 · 2.4K citations

Medicine, Neuroscience, Pharmacology +10

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14