Concepedia

Accelerated, aging‐dependent development of osteoarthritis in α1 integrin–deficient mice

Michihisa Zemmyo, E. John Meharra, Klaus Kühn, Lilo Creighton‐Achermann, Martin Lotz

Arthritis & Rheumatism · 2003 · 156 citations · 41 references

DOI

Abstract

Deficiency in the alpha1 integrin subunit is associated with an earlier deregulation of cartilage homeostasis and an accelerated, aging-dependent development of OA.

References

41

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

Kishore K. Wary, Fabrizio Mainiero, Steven J. Isakoff et al. · Cell · 1996 · 737 citations · Full text

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

Kishore K. Wary, Agnese Mariotti, Chiara Zurzolo et al. · Cell · 1998 · 715 citations · Full text

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Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology

Francisco J. Blanco, Ram�n Guitian, Eduardo V�zquez-Martul et al. · Arthritis & Rheumatism · 1998 · 594 citations

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

Shila Jalali, Miguel Á. del Pozo, Kuang‐Den Chen et al. · Proceedings of the National Academy of Sciences · 2001 · 411 citations · Full text

Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis

Sanshiro Hashimoto, Kenji Takahashi, David Amiel et al. · Arthritis & Rheumatism · 1998 · 343 citations