Copper-mediated One-pot Synthesis of Trifluorostyrene Derivatives from Tetrafluoroethylene and Arylboronate

Abstract

Abstract We developed the copper-mediated synthesis of trifluorostyrene derivatives. β-Fluorine elimination of a 2-aryl-1,1,2,2-tetrafluoroethylcopper complex, generated in situ from arylboronate, copper tert-butoxide, and 1,10-phenanthroline with tetrafluoroethylene (TFE) via carbocupration, was promoted by the addition of a Lewis acid. The present reaction system was applied to the one-pot synthesis of various trifluorostyrene derivatives, through the transmetalation–carbocupration–β-fluorine elimination sequence.