Solid‐phase synthesis of RNA via a silyl‐protecting‐group strategy

Abstract

Abstract Ribonucleoside phosphoramidites have been prepared of which the exocyclic amino functions and 2′‐hydroxyl functions are protected with 2‐[( tert ‐butyldiphenylsiloxy)methyl]benzoyl groups and tert ‐butyldimethylsilyl groups, respectively. The N ‐SiOMB/ O ‐TBDMS‐blocked nucleosides proved to be suitable building units in a solid‐phase synthesis of the RNA‐fragment 5′‐AGAGUACCU‐3′ via a phosphite triester approach.