Protective group-free synthesis of new chiral diamines via direct azidation of 1,1-diaryl-2-aminoethanols

Abstract

A direct azidation of tertiary alcohols using sodium azide–sulfuric acid is described; the present method provides an efficient and practical path for the synthesis of new chiral diamines from unmasked 1,1-diaryl-2-aminoethanols derived from natural amino acids.