In Vivo Formation of 8-Iso-Prostaglandin F_2αand Platelet Activation in Diabetes Mellitus

Abstract

We conclude that DM is associated with increased formation of F2-isoprostanes, as a correlate of impaired glycemic control and enhanced lipid peroxidation. This may provide an important biochemical link between impaired glycemic control and persistent platelet activation. These results provide a rationale for dose-finding studies of antioxidant treatment in diabetes.