The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells

Initial sequencing and analysis of the human genome

Eric S. Lander, Lauren Linton, Bruce W. Birren et al. · Nature · 2001 · 24.6K citations · Full text

Life Sciences, Genetics, Human Development +10

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

Bernard J. Poiesz, Francis W. Ruscetti, Adi F. Gazdar et al. · Proceedings of the National Academy of Sciences · 1980 · 5.1K citations · Full text

Life Sciences, Cell Biology, Microbiology +12

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

Isao Miyoshi, Ichiro Kubonishi, S Yoshimoto et al. · Nature · 1981 · 1.4K citations

Life Sciences, Immunology, Microbiology +11

Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

Jayne M. Stommel, Alec C. Kimmelman, Haoqiang Ying et al. · Science · 2007 · 928 citations

Medicine, Cancer Biology, Oncology +17

Regulation of myeloid leukaemia by the cell-fate determinant Musashi

Takahiro Ito, Hyog Young Kwon, Bryan Zimdahl et al. · Nature · 2010 · 366 citations · Full text

Life Sciences, Cancer Biology, Cell Biology +14