Manganese catalysed sulfenylation of N-methyl amides with arenesulfonyl hydrazides

Abstract

A convenient oxidative sulfenylation method for the formation of various sulfenyl amides has been reported. Arenesulfonyl hydrazine as a sulfur source in the presence of a manganese salt can activate the sp(3) C-H bond of N-methyl amides through a free-radical pathway using di-tert-butyl peroxide (DTBP).