British Journal of Pharmacology · 1981 · 59 citations · 9 references
MedicineNeurosciencePharmacologyNeurochemistryNeuropharmacologyPharmacodynamicsCholinergic NeurochemistryCholinergic PharmacologyCholinergic SignalingNeurochemical PharmacologyNeuromuscular JunctionAcetylcholine PharmacologyAnticholinergic DrugsCholinergic AgonistsCholinergic Receptor PharmacologyMuscarinic Receptor AntagonismMuscarinic Receptor PharmacologyMuscarinic ReceptorsPresynaptic Cholinergic Regulation
1 Atropine (10(-5) M) enhanced the release of [3H]-acetylcholine from rat isolated hemidiaphragms, previously incubated with [3H-methyl]-choline, stimulated via their phrenic nerves. 2 Oxotremorine (10(-5) M) did not affect the stimulated release of [3H]-acetylcholine but antagonized the facilitatory effects of atropine (10(-5) M). 3 It is suggested that there are presynaptic inhibitory muscarinic receptors that modulate the release of acetylcholine in the phrenic nerves of the rat.
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