Sensitivities of bleomycin-resistant variant cells enhanced by 40°C hyperthermia<i>in vitro</i>

Abstract

Cultured mammalian cells of higher (mouse L) and lower (Chinese hamster V-79) sensitivities to bleomycin (BLM) were repeatedly treated with BLM (0.1 mg/ml), through which BLM-resistant variant strains were induced. Sensitivities of these variant strains to BLM were enhanced by simultaneous treatment with 40 degrees C hyperthermia.