The use of pharmacoscintigraphy to focus the development strategy for a novel 5-ASA colon targeting system (“TIME CLOCK®” system)

Transit of pharmaceutical dosage forms through the small intestine.

S.S. Davis, John G. Hardy, J W Fara · Gut · 1986 · 848 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

An oral preparation to release drugs in the human colon.

M. J. Dew, PJ Hughes, MG Lee et al. · British Journal of Clinical Pharmacology · 1982 · 186 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

The time clock system: a new oral dosage form for fast and complete release of drug after a predetermined lag time☆

Flavio Pozzi, Pia Furlani, A. Gazzaniga et al. · Journal of Controlled Release · 1994 · 150 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +13

Evaluation of an enteric‐coated delayed‐release 5‐aminosalicylic acid tablet in patients with inflammatory bowel disease

J. G. HARDY, J. N. C. HEALEY, J. R. Reynolds · Alimentary Pharmacology & Therapeutics · 1987 · 96 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Enteric coated timed release systems for colonic targeting

Ian R. Wilding, S.S. Davis, Flavio Pozzi et al. · International Journal of Pharmaceutics · 1994 · 73 citations

Pharmacy, Bioengineering, Pharmaceutics +14