Cancer · 1993 · 116 citations · 15 references
MedicineSurgeryUrologyGenitourinary OncologySurgical OncologyUrologic SurgeryGenitourinary Cancer RadiotherapyGenitourinary Cancer SurgeryProstate CancerProstate SurgeryRadiation Therapy For Prostate DiseaseRadical ProstatectomyClose Surgical MarginsNegative Surgical MarginsPositive Surgical MarginsPostoperative Ureteral InjuryProximal Ureteral InjurySalvage ProstatectomySalvage Radical ProstatectomySurgical Resection Margins
METHODS: Salvage surgery was done in 43 patients who did not respond to radiation therapy of prostate cancer between 1982-1991. Thirty-five patients underwent salvage prostatectomy and 8, cystoprostatectomy. RESULTS: The complications were significant; four patients had rectal injuries (all closed primarily), one had a ureteral injury, and there was one perioperative death. Urinary incontinence occurred in 10 of 35 patients (30%). Pathologic step sections of the prostate showed that only 13 of 43 patients (30%) had negative surgical margins. Follow-up (range, 1-10 years) revealed that 34 patients were alive, and 9 had died. Eleven of 20 patients were alive who were followed more than 5 years. Ten patients were considered to have no evidence of disease (undetectable prostate specific antigen levels). CONCLUSION: In selected patients, salvage surgery has a place in the treatment of prostate cancer after radiation therapy failure.
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Carcinoma of the prostate: Results of post‐irradiation biopsy
Fuad S. Freiha, Malcolm A. Bagshaw · The Prostate · 1984 · 187 citations