FEBS Letters · 1987 · 50 citations · 3 references
Life SciencesMicrobiologyBiophysical ChemistryMicrobial GeneticsMolecular RecognitionRibonucleic Acid (Rna) ChemistryRibosome FunctionAntibiotic Binding Sites On The RibosomeAntibiotic Interactions With TetracyclinesEscherichia ColiTetracycline AntibioticsTetracycline InteractionsTrna Binding Sites
Fluorescence anisotropy studies performed on 6-demethylchlortetracycline, binding to the ribosome of E. coli in competition with tRNA at the P site or at both P and A sites, have provided a quantitative assessment in situ of the interaction of this antibiotic with the A site and have demonstrated that there is also an interaction between tetracycline and the P site.
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