Minimal Dose for Severe Poisoning and Influencing Factors in Acute Human Clozapine Intoxication

Abstract

Moderate and severe clozapine intoxications can already occur after ingestion of doses in the low therapeutic range, especially in patients older than 50 years. Poisoned patients have to be monitored for central nervous system depression, tachycardia, blood pressure abnormalities, respiratory depression, and QTc prolongation.