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Should therapeutic drug monitoring of the unbound fraction of imatinib and its main active metabolite N-desmethyl-imatinib be developed?

Therapeutic Drug MonitoringMedicinal ChemistryBiochemistryUnbound FractionMain Active MetaboliteMedicineBioanalysisNatural SciencesDrug MonitoringPharmacotherapyAnti-cancer AgentDrug DevelopmentMetabolomicsPharmacologyDrug DiscoveryPharmaceutical ResearchDrug Analysis