Room-Temperature Suzuki−Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles

Abstract

Use of a dilute aqueous solution containing a nonionic amphiphile allows efficient Suzuki-Miyaura cross-couplings of arylboronic acids with a wide array of aryl halides and pseudohalides, including sterically hindered and lipophilic substrates, in most cases at room temperature.