Concepedia

Discovery of Diarylacrylonitriles as a Novel Series of Small Molecule Sortase A Inhibitors

Ki-Bong Oh, Soo Hwan Kim, Jae-Kwang Lee, Won-Jea Cho, Tae‐Ho Lee, Sanghee Kim

Journal of Medicinal Chemistry · 2004 · 121 citations · 19 references

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Abstract

On the basis of a hit from random screening, a novel class of small-molecule sortase A inhibitors was generated. The primary structure-activity relationship and the minimal structural requirements for potency were established through structural modifications and molecular modeling studies.

References

19

<i>Staphylococcus aureus</i> Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall

Sarkis K. Mazmanian, Gwen Liu, Hung Ton‐That et al. · Science · 1999 · 1K citations

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Estrogen Receptor-β Potency-Selective Ligands:  Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues

Marvin J. Meyers, Jun Sun, Kathryn E. Carlson et al. · Journal of Medicinal Chemistry · 2001 · 678 citations · Full text

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Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of <i>Staphylococcus aureus</i> at the LPXTG motif

Hung Ton‐That, Gwen Liu, Sarkis K. Mazmanian et al. · Proceedings of the National Academy of Sciences · 1999 · 572 citations · Full text

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Sorting of protein a to the staphylococcal cell wall

Olaf Schneewind, Peter Model, Vincent A. Fischetti · Cell · 1992 · 560 citations

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<i>Staphylococcus aureus</i> sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections

Sarkis K. Mazmanian, Gwen Liu, Eric R. Jensen et al. · Proceedings of the National Academy of Sciences · 2000 · 453 citations

, , +17