Partial Resolution of DL-Adenosine by Template Synthesis

Abstract

D-Adenosine-5'-phosphorimidazolide reacts very much more rapidly with D-adenosine than with L-adenosine on a poly-D-uridylic acid template. This permits the partial resolution of DL-adenosine. These experiments suggest that segregation of D- and L-nucleotides may have occurred at an early stage in biochemical evolution.