Pioglitazone prevents corporal veno‐occlusive dysfunction in a rat model of type 2 diabetes mellitus

Abstract

Type 2 diabetes in Zucker fa/fa rats was associated with penile corporal fibrosis, oxidative stress, and CVOD, which were ameliorated by long-term low-dose pioglitazone, suggesting that this drug might protect the SM, independently from its antidiabetic effect.