Progressive specific immune attrition after primary, secondary and tertiary immunizations with bacteriophage ΦX174 in asymptomatic HIV-1 infected patients

Abstract

Multiple boosters of immunizations in asymptomatic treatment-naive HIV-1-infected patients may result in a specific immune attrition and vaccine-induced viremia. Short-term monotherapy with ZDV may have blunted these adverse effects. Hyperimmunization of HIV-1-infected patients may be detrimental unless accompanied by antiretroviral therapy.