BIOCHEMICAL BEHAVIOR OF THIO-AZOMETHINE DIFLUORO-BORON COMPOUNDS

Abstract

Abstract Fluoroboron(III) complexes of the azomethines derived from heterocyclic aldehydes and 2-mercaptoaniline have been characterized on the basis of I.R., 1H, 11B and 19F N.M.R. spectral studies along with elemental analyses, conductivity measurements and molecular weight determinations. The equimolar reactions between borontrifluoride diacetic acid and these thio-azomethines have afforded biologically active (azomethine) BF2 compounds in which the central atom appears to be in a tetracoordinated state. These thio-azomethines along with their complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential.