The Myotoxic Effect of Bupivacaine and Ropivacaine on Myotubes in Primary Mouse Cell Culture and an Immortalized Cell Line

Abstract

Primary skeletal muscle cells are more vulnerable to LAs than immortalized cells. The higher myotoxic potential of bupivacaine compared with ropivacaine in vivo can be reproduced in vitro. Incubation time has an influence on cell survival.