The SAG1<i>Toxoplasma gondii</i>Surface Protein Is Not Required for Acute Ocular Toxoplasmosis in Mice

Abstract

The SAG1 Toxoplasma gondii surface protein stimulates acute ileitis. To determine whether SAG1 is also important in the eye, wild-type or SAG1 knockout parasites were injected intravitreally into mice. No differences in retinal damage or parasite growth were observed, indicating that unlike the case for the intestine, factors besides SAG1 are important for retinal damage.